Clever people do clever things with the format of books all the time, usually creating something that is as much artefact as book. S., by J J Abrams and Doug Dorst, for instance:
Or the recently published limited edition of Chang-rae Lee’s novel, On Such a Full Sea, which comes in a 3D printed white slipcase (more details, and a video here):
But such innovation is far from a modern phenomenon. In fact, a book bound in Germany in the 16th century far outclasses anything I have seen produced in the 21st century. Behold! The magical book that opens six ways!
This book is held by the National Library of Sweden, who have shared their photos of this book and more over on Flickr.